First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood
Identifieur interne : 001937 ( Main/Exploration ); précédent : 001936; suivant : 001938First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood
Auteurs : Weimin Zhou ; Wen Wang ; Huijuan Wang ; Roujian Lu ; Wenjie TanSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (immunologie), Coronavirus (génétique), Coronavirus (immunologie), Coronavirus (isolement et purification), Coronavirus (physiologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Jeune adulte, Mâle, Nourrisson, Sujet âgé.
- MESH :
- diagnostic : Infections à coronavirus.
- génétique : Coronavirus.
- immunologie : Anticorps antiviraux, Coronavirus, Infections à coronavirus.
- isolement et purification : Coronavirus.
- physiologie : Coronavirus.
- virologie : Infections à coronavirus.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antibodies, Viral (immunology), Child, Child, Preschool, Coronavirus (genetics), Coronavirus (immunology), Coronavirus (isolation & purification), Coronavirus (physiology), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Coronavirus Infections (virology), Female, Humans, Infant, Male, Middle Aged, Young Adult.
- MESH :
- chemical , immunology : Antibodies, Viral.
- diagnosis : Coronavirus Infections.
- genetics : Coronavirus.
- immunology : Coronavirus, Coronavirus Infections.
- isolation & purification : Coronavirus.
- physiology : Coronavirus.
- virology : Coronavirus Infections.
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Young Adult.
Abstract
Non-severe acute respiratory syndrome (non-SARS)-related human coronaviruses (HCoVs), including HCoV-229E, -HKU1, -NL63, and -OC43, have been detected in respiratory tract samples from children and adults. However, the natural prevalence of antibodies against these viruses in serum among population is unknown.
To measure antibodies to the spike (S) protein of the four common non-SARS HCoVs, recombinant S proteins of the four HCoVs were expressed and characterised in 293 T cell. An S-protein-based indirect immunofluorescence assay (IFA) was then developed to detect anti-S IgG and IgM for the four individual HCoVs and applied to serum samples from a general asymptomatic population (218 children and 576 adults) in Beijing.
Of 794 blood samples tested, only 29 (3.65%) were negative for anti-S IgG. The seropositivity of the four anti-S IgG antibodies was >70% within the general population. The majority of seroconversions to four-HCoV positivity first occurred in children. Both S-IgG and S-IgM antibodies were detectable among children and increased with age, reaching a plateau at 6 years of age. However, no anti-S IgM was detected in healthy adults.
Large proportions of children and adults in Beijing have evidence of anti-S IgG against four the HCoVs, and first infections by all four non-SARS HCoVs takes place during childhood.
The online version of this article (doi:10.1186/1471-2334-13-433) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1471-2334-13-433
PubMed: 24040960
PubMed Central: 3848659
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000301
- to stream Pmc, to step Curation: 000301
- to stream Pmc, to step Checkpoint: 000984
- to stream PubMed, to step Corpus: 001127
- to stream PubMed, to step Curation: 001127
- to stream PubMed, to step Checkpoint: 001178
- to stream Ncbi, to step Merge: 002752
- to stream Ncbi, to step Curation: 002752
- to stream Ncbi, to step Checkpoint: 002752
- to stream Main, to step Merge: 001945
- to stream Main, to step Curation: 001937
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood</title><author><name sortKey="Zhou, Weimin" sort="Zhou, Weimin" uniqKey="Zhou W" first="Weimin" last="Zhou">Weimin Zhou</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Lu, Roujian" sort="Lu, Roujian" uniqKey="Lu R" first="Roujian" last="Lu">Roujian Lu</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24040960</idno><idno type="pmc">3848659</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848659</idno><idno type="RBID">PMC:3848659</idno><idno type="doi">10.1186/1471-2334-13-433</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000301</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000301</idno><idno type="wicri:Area/Pmc/Curation">000301</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000301</idno><idno type="wicri:Area/Pmc/Checkpoint">000984</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000984</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:24040960</idno><idno type="wicri:Area/PubMed/Corpus">001127</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001127</idno><idno type="wicri:Area/PubMed/Curation">001127</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001127</idno><idno type="wicri:Area/PubMed/Checkpoint">001178</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001178</idno><idno type="wicri:Area/Ncbi/Merge">002752</idno><idno type="wicri:Area/Ncbi/Curation">002752</idno><idno type="wicri:Area/Ncbi/Checkpoint">002752</idno><idno type="wicri:Area/Main/Merge">001945</idno><idno type="wicri:Area/Main/Curation">001937</idno><idno type="wicri:Area/Main/Exploration">001937</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood</title><author><name sortKey="Zhou, Weimin" sort="Zhou, Weimin" uniqKey="Zhou W" first="Weimin" last="Zhou">Weimin Zhou</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Lu, Roujian" sort="Lu, Roujian" uniqKey="Lu R" first="Roujian" last="Lu">Roujian Lu</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antibodies, Viral (immunology)</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus (genetics)</term><term>Coronavirus (immunology)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (immunologie)</term><term>Coronavirus (génétique)</term><term>Coronavirus (immunologie)</term><term>Coronavirus (isolement et purification)</term><term>Coronavirus (physiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Coronavirus</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Non-severe acute respiratory syndrome (non-SARS)-related human coronaviruses (HCoVs), including HCoV-229E, -HKU1, -NL63, and -OC43, have been detected in respiratory tract samples from children and adults. However, the natural prevalence of antibodies against these viruses in serum among population is unknown.</p></sec><sec><title>Methods</title><p>To measure antibodies to the spike (S) protein of the four common non-SARS HCoVs, recombinant S proteins of the four HCoVs were expressed and characterised in 293 T cell. An S-protein-based indirect immunofluorescence assay (IFA) was then developed to detect anti-S IgG and IgM for the four individual HCoVs and applied to serum samples from a general asymptomatic population (218 children and 576 adults) in Beijing.</p></sec><sec><title>Results</title><p>Of 794 blood samples tested, only 29 (3.65%) were negative for anti-S IgG. The seropositivity of the four anti-S IgG antibodies was >70% within the general population. The majority of seroconversions to four-HCoV positivity first occurred in children. Both S-IgG and S-IgM antibodies were detectable among children and increased with age, reaching a plateau at 6 years of age. However, no anti-S IgM was detected in healthy adults.</p></sec><sec><title>Conclusion</title><p>Large proportions of children and adults in Beijing have evidence of anti-S IgG against four the HCoVs, and first infections by all four non-SARS HCoVs takes place during childhood.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1471-2334-13-433) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lai, Mmc" uniqKey="Lai M">MMC Lai</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamre, D" uniqKey="Hamre D">D Hamre</name></author><author><name sortKey="Procknow, Jj" uniqKey="Procknow J">JJ Procknow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author><author><name sortKey="Bynoe, Ml" uniqKey="Bynoe M">ML Bynoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author><author><name sortKey="Jebbink, Mf" uniqKey="Jebbink M">MF Jebbink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Sb" uniqKey="Greenberg S">SB Greenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brian, Da" uniqKey="Brian D">DA Brian</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dare, Rk" uniqKey="Dare R">RK Dare</name></author><author><name sortKey="Fry, Am" uniqKey="Fry A">AM Fry</name></author><author><name sortKey="Chittaganpitch, M" uniqKey="Chittaganpitch M">M Chittaganpitch</name></author><author><name sortKey="Sawanpanyalert, P" uniqKey="Sawanpanyalert P">P Sawanpanyalert</name></author><author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name></author><author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaunt, Er" uniqKey="Gaunt E">ER Gaunt</name></author><author><name sortKey="Hardie, A" uniqKey="Hardie A">A Hardie</name></author><author><name sortKey="Claas, Ecj" uniqKey="Claas E">ECJ Claas</name></author><author><name sortKey="Simmonds, P" uniqKey="Simmonds P">P Simmonds</name></author><author><name sortKey="Templeton, Ke" uniqKey="Templeton K">KE Templeton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehmann, C" uniqKey="Lehmann C">C Lehmann</name></author><author><name sortKey="Wolf, H" uniqKey="Wolf H">H Wolf</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Severance, Eg" uniqKey="Severance E">EG Severance</name></author><author><name sortKey="Bossis, I" uniqKey="Bossis I">I Bossis</name></author><author><name sortKey="Dickerson, Fb" uniqKey="Dickerson F">FB Dickerson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, X" uniqKey="Shao X">X Shao</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Esper, F" uniqKey="Esper F">F Esper</name></author><author><name sortKey="Weibel, C" uniqKey="Weibel C">C Weibel</name></author><author><name sortKey="Kahn, Js" uniqKey="Kahn J">JS Kahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Jebbink, Mf" uniqKey="Jebbink M">MF Jebbink</name></author><author><name sortKey="El Idrissi, Nb" uniqKey="El Idrissi N">NB El Idrissi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geoffrey, Jg" uniqKey="Geoffrey J">JG Geoffrey</name></author><author><name sortKey="Gira, Bp" uniqKey="Gira B">BP Gira</name></author><author><name sortKey="Joseph, Nv" uniqKey="Joseph N">NV Joseph</name></author><author><name sortKey="Theresa, Zo" uniqKey="Theresa Z">ZO Theresa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maache, M" uniqKey="Maache M">M Maache</name></author><author><name sortKey="Komurian Pradel, F" uniqKey="Komurian Pradel F">F Komurian-Pradel</name></author><author><name sortKey="Rajoharison, A" uniqKey="Rajoharison A">A Rajoharison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gimenez, Lg" uniqKey="Gimenez L">LG Giménez</name></author><author><name sortKey="Rojas, J" uniqKey="Rojas J">J Rojas</name></author><author><name sortKey="Rojas, A" uniqKey="Rojas A">A Rojas</name></author><author><name sortKey="Mendoza, J" uniqKey="Mendoza J">J Mendoza</name></author><author><name sortKey="Camacho, Ag" uniqKey="Camacho A">AG Camacho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Zy" uniqKey="Yang Z">ZY Yang</name></author><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Nolan, E" uniqKey="Nolan E">E Nolan</name></author><author><name sortKey="Kreitschitz, S" uniqKey="Kreitschitz S">S Kreitschitz</name></author><author><name sortKey="Rabussay, Dp" uniqKey="Rabussay D">DP Rabussay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garbino, J" uniqKey="Garbino J">J Garbino</name></author><author><name sortKey="Crespo, S" uniqKey="Crespo S">S Crespo</name></author><author><name sortKey="Aubert, Jd" uniqKey="Aubert J">JD Aubert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haynes, Lm" uniqKey="Haynes L">LM Haynes</name></author><author><name sortKey="Miao, C" uniqKey="Miao C">C Miao</name></author><author><name sortKey="Harcourt, Jl" uniqKey="Harcourt J">JL Harcourt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Cm" uniqKey="Chan C">CM Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name></author><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Cm" uniqKey="Chan C">CM Chan</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradburne, Af" uniqKey="Bradburne A">AF Bradburne</name></author><author><name sortKey="Bynoe, Ml" uniqKey="Bynoe M">ML Bynoe</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradburne, Af" uniqKey="Bradburne A">AF Bradburne</name></author><author><name sortKey="Somerset, Ba" uniqKey="Somerset B">BA Somerset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Callow, Ka" uniqKey="Callow K">KA Callow</name></author><author><name sortKey="Parry, Hf" uniqKey="Parry H">HF Parry</name></author><author><name sortKey="Sergeant, M" uniqKey="Sergeant M">M Sergeant</name></author><author><name sortKey="Tyrrell, Da" uniqKey="Tyrrell D">DA Tyrrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hasony, Hj" uniqKey="Hasony H">HJ Hasony</name></author><author><name sortKey="Macnaughton, Mr" uniqKey="Macnaughton M">MR Macnaughton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraaijeveld, Ca" uniqKey="Kraaijeveld C">CA Kraaijeveld</name></author><author><name sortKey="Reed, Se" uniqKey="Reed S">SE Reed</name></author><author><name sortKey="Macnaughton, Mr" uniqKey="Macnaughton M">MR Macnaughton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H Hofmann</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name></author><author><name sortKey="Geier, M" uniqKey="Geier M">M Geier</name></author><author><name sortKey="Berkhout, B" uniqKey="Berkhout B">B Berkhout</name></author><author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S Pohlmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Principi, N" uniqKey="Principi N">N Principi</name></author><author><name sortKey="Bosis, S" uniqKey="Bosis S">S Bosis</name></author><author><name sortKey="Esposito, S" uniqKey="Esposito S">S Esposito</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lu, Roujian" sort="Lu, Roujian" uniqKey="Lu R" first="Roujian" last="Lu">Roujian Lu</name><name sortKey="Tan, Wenjie" sort="Tan, Wenjie" uniqKey="Tan W" first="Wenjie" last="Tan">Wenjie Tan</name><name sortKey="Wang, Huijuan" sort="Wang, Huijuan" uniqKey="Wang H" first="Huijuan" last="Wang">Huijuan Wang</name><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><name sortKey="Zhou, Weimin" sort="Zhou, Weimin" uniqKey="Zhou W" first="Weimin" last="Zhou">Weimin Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001937 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001937 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3848659
|texte= First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24040960" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |